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生物活性
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产品描述
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Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
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靶点活性
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TNF-α,
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应用领域
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Cancer
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实验溶液
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30% PEG400+0.5% Tween80+5% propylene glycol: 5 mg/mL
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体外活性
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Thalidomide选择性地抑制脂多糖和其他激动剂刺激人体单核细胞生产肿瘤坏死因子α。TThalidomide通过增强mRNA降解发挥其对肿瘤坏死因子α的抑制作用。Thalidomide通过诱导细胞凋亡和G1期生长停滞直接作用在MM细胞系以及抗美法仑，盐酸阿霉素和地塞米松的病人的MM细胞。
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体内活性
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200 mg/kg Thalidomide导致在兔子体内血管化角膜区的抑制，抑制率在三个实验中从30％到51％。
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化学信息
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分子量
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258.23
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分子式
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C13H10N2O4
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CAS
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50-35-1
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溶解度
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DMSO: 6.5 mg/mL (25 mM)
（ < 1 mg/ml refers to the product slightly soluble or insoluble )
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储存条件
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3 years -20℃ powder
2 years -80℃ In solvent
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备注
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For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
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