产品基本信息

货号：6902

产品名称：小沟结合物探针CDPI3-CPG*500A*

规格：100 mg

储存条件：-20℃干燥

保质期：12个月

产品物理化学光谱特性

外观：固体

溶剂：MeCN

产品介绍

小沟结合物（MGB）分子选择性地结合到DNA分子的小沟，即DNA螺旋中的浅沟。MGB标记的寡核苷酸与互补的DNA和RNA靶序列形成稳定的杂合复合物。天然产物CC-1065的类似物二氢吡咯并吲哚三肽（CDPI3）已表现出与寡核苷酸连接时可在单链DNA上阻止序列特异性引物延伸。包含CDPI3的寡核苷酸可提高特异性和杂交强度，从而增强DNA双链体的稳定性。将MGB分子添加到DNA探针可以设计出较短的杂交探针，该探针可用于分子诊断，例如基于定量PCR的测定。可能有几种设计，包括Taqman MGB探针。AAT Bioquest提供此CPG支持，可将MGB部分方便地添加到寡核苷酸的3’末端。我们还提供MGB亚磷酰胺，用于用MGB部分标记5’末端。

参考文献

Oligonucleotide-minor groove binder conjugates and their complexes with complementary DNA: effect of conjugate structural factors on the thermal stability of duplexes.
Authors: Ryabinin, Vladimir A and Boutorine, Alexandre S and Hélène, Claude and Pyshnyi, Dmitrii V and Sinyakov, Alexandre N
Journal: Nucleosides, nucleotides & nucleic acids (2004): 789-803

The preferential binding of histone H1 to DNA scaffold-associated regions is determined by its C-terminal domain.
Authors: Roque, Alicia and Orrego, Mary and Ponte, Imma and Suau, Pedro
Journal: Nucleic acids research (2004): 6111-9

Synthesis and evaluation of oligo-1,3-thiazolecarboxamide derivatives as HIV-1 reverse transcriptase inhibitors.
Authors: Ryabinin, V A and Zakharova, O D and Yurchenko, E Y and Timofeeva, O A and Martyanov, I V and Tokarev, A A and Belanov, E F and Bormotov, N I and Tarrago-Litvak, L and Andreola, M L and Litvak, S and Nevinsky, G A and Sinyakov, A N
Journal: Bioorganic & medicinal chemistry (2000): 985-93

[Effect of structural factors on the stability of duplexes formed by oligonucleotide conjugates with minor groove ligands].
Authors: Riabinin, V A and Butorin, A S and Elen, K and Denisov, A Iu and Pyshnyĭ, D V and Siniakov, A N
Journal: Bioorganicheskaia khimiia: 159-66

产品基本信息

货号：6908

产品名称：小沟结合物探针CDPI3马来酰亚胺

规格：1 mg

储存条件：-20℃干燥

保质期：12个月

产品物理化学光谱特性

外观：固体

分子量：888.99

溶剂：DMSO

产品介绍

小沟结合物（MGB）分子选择性地结合到DNA分子的小沟，即DNA螺旋中的浅沟。MGB标记的寡核苷酸与互补的DNA和RNA靶序列形成稳定的杂合复合物。天然产物CC-1065的类似物二氢吡咯并吲哚三肽（CDPI3）已表现出与寡核苷酸连接时可在单链DNA上阻止序列特异性引物延伸。包含CDPI3的寡核苷酸可提高特异性和杂交强度，从而增强DNA双链体的稳定性。将MGB分子添加到DNA探针可以设计出较短的杂交探针，该探针可用于分子诊断，例如基于定量PCR的测定。可能有几种设计，包括Taqman MGB探针。AAT Bioquest提供此CPG支持，可将MGB部分方便地添加到寡核苷酸的3’末端。我们还提供MGB亚磷酰胺，用于用MGB部分标记5’末端。

产品基本信息

货号：6900

产品名称：小沟结合物探针CDPI3-CPG*500A*

规格：100 mg

储存条件：-20℃干燥

保质期：12个月

产品物理化学光谱特性

外观：固体

溶剂：MeCN

产品介绍

小沟结合物（MGB）分子选择性地结合到DNA分子的小沟，即DNA螺旋中的浅沟。MGB标记的寡核苷酸与互补的DNA和RNA靶序列形成稳定的杂合复合物。天然产物CC-1065的类似物二氢吡咯并吲哚三肽（CDPI3）已表现出与寡核苷酸连接时可在单链DNA上阻止序列特异性引物延伸。包含CDPI3的寡核苷酸可提高特异性和杂交强度，从而增强DNA双链体的稳定性。将MGB分子添加到DNA探针可以设计出较短的杂交探针，该探针可用于分子诊断，例如基于定量PCR的测定。可能有几种设计，包括Taqman MGB探针。AAT Bioquest提供此CPG支持，可将MGB部分方便地添加到寡核苷酸的3’末端。我们还提供MGB亚磷酰胺，用于用MGB部分标记5’末端。

参考文献

Capecitabine as a minor groove binder of DNA: molecular docking, molecular dynamics, and multi-spectroscopic studies.
Authors: Zhang, Shuangshuang and Yang, Hongqin and Zhao, Ludan and Gan, Ruixue and Tang, Peixiao and Sun, Qiaomei and Xiong, Xinnuo and Li, Hui
Journal: Journal of biomolecular structure & dynamics (2019): 1451-1463

Minor groove binder modification of widely used TaqMan hydrolysis probe for detection of dengue virus reduces risk of false-negative real-time PCR results for serotype 4.
Authors: Gray, Eleanor R and Heaney, Judith and Ferns, R Bridget and Sequeira, Patricia C and Nastouli, Eleni and Garson, Jeremy A
Journal: Journal of virological methods (2019): 17-23

A rapid minor groove binder PCR method for distinguishing the vaccine strain Brucella abortus 104M.
Authors: Nan, Wenlong and Qin, Lide and Wang, Yong and Zhang, Yueyong and Tan, Pengfei and Chen, Yuqi and Mao, Kairong and Chen, Yiping
Journal: BMC veterinary research (2018): 27

Influence of Divalent Counterions on the Dynamics in DNA as Probed by Using a Minor-Groove Binder.
Authors: Paul, Sneha and Ahmed, Tasnim and Samanta, Anunay
Journal: Chemphyschem : a European journal of chemical physics and physical chemistry (2017): 2058-2064

Origin of DNA-Induced Circular Dichroism in a Minor-Groove Binder.
Authors: Holmgaard List, Nanna and Knoops, Jérémie and Rubio-Magnieto, Jenifer and Idé, Julien and Beljonne, David and Norman, Patrick and Surin, Mathieu and Linares, Mathieu
Journal: Journal of the American Chemical Society (2017): 14947-14953

Development of a real-time quantitative PCR assay using a TaqMan minor groove binder probe for the detection of α-lactalbumin in food.
Authors: Xiao, Guan and Qin, Cai and Wenju, Zhang and Qin, Chen
Journal: Journal of dairy science (2016): 1716-1724

Grandivittin as a natural minor groove binder extracted from Ferulago macrocarpa to ct-DNA, experimental and in silico analysis.
Authors: Ahmadi, F and Valadbeigi, S and Sajjadi, S E and Shokoohinia, Y and Azizian, H and Taheripak, G
Journal: Chemico-biological interactions (2016): 89-101

Synthesis of a novel 4H-pyran analog as minor groove binder to DNA using ethidium bromide as fluorescence probe.
Authors: Ramana, M M V and Betkar, Rahul and Nimkar, Amey and Ranade, Prasanna and Mundhe, Balaji and Pardeshi, Sachin
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2016): 165-71

Dacarbazine as a minor groove binder of DNA: Spectroscopic, biophysical and molecular docking studies.
Authors: Ahmad, Irshad and Ahmad, Masood
Journal: International journal of biological macromolecules (2015): 193-200

Demonstration of the Pre-Emergency Use Authorization Path Using 3 Minor Groove Binder-Hydrolysis Probe Assays to Detect Escherichia coli O104:H4.
Authors: Hartman, Laurie J and Heinrich, Megan L and Zovanyi, Ashley M and Ingram, Michael F and Hobson, J Peyton and Kulesh, David A and Craw, Philip D and Jaissle, James G and Norwood, David A and Minogue, Timothy D
Journal: Clinical chemistry (2015): 1391-8

产品基本信息

货号：6907

产品名称：小沟结合物探针CDPI3琥珀酰亚胺酯

规格：1 mg

储存条件：-20℃干燥

保质期：12个月

产品物理化学光谱特性

外观：固体

分子量：863.93

溶剂：DMSO

产品介绍

小沟结合物（MGB）分子选择性地结合到DNA分子的小沟，即DNA螺旋中的浅沟。MGB标记的寡核苷酸与互补的DNA和RNA靶序列形成稳定的杂合复合物。天然产物CC-1065的类似物二氢吡咯并吲哚三肽（CDPI3）已表现出与寡核苷酸连接时可在单链DNA上阻止序列特异性引物延伸。包含CDPI3的寡核苷酸可提高特异性和杂交强度，从而增强DNA双链体的稳定性。将MGB分子添加到DNA探针可以设计出较短的杂交探针，该探针可用于分子诊断，例如基于定量PCR的测定。可能有几种设计，包括Taqman MGB探针。AAT Bioquest提供此CPG支持，可将MGB部分方便地添加到寡核苷酸的3’末端。我们还提供MGB亚磷酰胺，用于用MGB部分标记5’末端。

参考文献

Carbocyclic Analogues of Distamycin and Netropsin.
Authors: Arciszewska, Karolina and Pućkowska, Anna and Wróbel, Agnieszka and Drozdowska, Danuta
Journal: Mini reviews in medicinal chemistry (2019): 98-113

Synthesis of a novel 4H-pyran analog as minor groove binder to DNA using ethidium bromide as fluorescence probe.
Authors: Ramana, M M V and Betkar, Rahul and Nimkar, Amey and Ranade, Prasanna and Mundhe, Balaji and Pardeshi, Sachin
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2016): 165-71

Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines.
Authors: Ríos Martínez, Carlos H and Lagartera, Laura and Kaiser, Marcel and Dardonville, Christophe
Journal: European journal of medicinal chemistry (2014): 481-91

Classification of DNA minor and major grooves binding proteins according to the NLSs by data analysis methods.
Authors: Amanzadeh, Elnaz and Mohabatkar, Hassan and Biria, Davoud
Journal: Applied biochemistry and biotechnology (2014): 437-51

Multi-spectroscopic and molecular modeling studies on the interaction of antihypertensive drug; methyldopa with calf thymus DNA.
Authors: Shahabadi, Nahid and Maghsudi, Maryam
Journal: Molecular bioSystems (2014): 338-47

Quantitation of substitutions at amino acid 70 in hepatitis C virus genotype 1b.
Authors: Hu, Zhongjie and Liu, Ying and Qiu, Lixia and Fan, Zuopeng and Nie, Wei and Liang, Shan and Jin, Ronghua
Journal: Virology journal (2014): 148

Minor groove binders as anti-infective agents.
Authors: Barrett, Michael P and Gemmell, Curtis G and Suckling, Colin J
Journal: Pharmacology & therapeutics (2013): 12-23

Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles; structure-activity relationships.
Authors: Tercel, Moana and Stevenson, Ralph J and Lu, Guo-Liang and Stribbling, Stephen M and Wilson, William R and Tatnell, Michele A and Marnane, Rebecca N and Mountjoy, Kathleen G and Denny, William A
Journal: Bioorganic & medicinal chemistry (2012): 734-49

Characterization of Canine parvovirus 2 variants circulating in Greece.
Authors: Ntafis, Vasileios and Xylouri, Eftychia and Kalli, Iris and Desario, Costantina and Mari, Viviana and Decaro, Nicola and Buonavoglia, Canio
Journal: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc (2010): 737-40

Quantification of RNA editing of the serotonin 2C receptor (5-HT(₂C)R) ex vivo.
Authors: Lanfranco, Maria Fe and Anastasio, Noelle C and Seitz, Patricia K and Cunningham, Kathryn A
Journal: Methods in enzymology (2010): 311-28

产品基本信息

货号：6909

产品名称：小沟结合物探针CDPI3马来酰亚胺

规格：1 mg

储存条件：-20℃干燥

保质期：12个月

产品物理化学光谱特性

外观：固体

分子量：834.94

溶剂：DMSO

产品介绍

小沟结合物（MGB）分子选择性地结合到DNA分子的小沟，即DNA螺旋中的浅沟。MGB标记的寡核苷酸与互补的DNA和RNA靶序列形成稳定的杂合复合物。天然产物CC-1065的类似物二氢吡咯并吲哚三肽（CDPI3）已表现出与寡核苷酸连接时可在单链DNA上阻止序列特异性引物延伸。包含CDPI3的寡核苷酸可提高特异性和杂交强度，从而增强DNA双链体的稳定性。将MGB分子添加到DNA探针可以设计出较短的杂交探针，该探针可用于分子诊断，例如基于定量PCR的测定。可能有几种设计，包括Taqman MGB探针。AAT Bioquest提供此CPG支持，可将MGB部分方便地添加到寡核苷酸的3’末端。我们还提供MGB亚磷酰胺，用于用MGB部分标记5’末端。

参考文献

Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29).
Authors: Chakraborty, Biswajit and Dutta, Debasmita and Mukherjee, Sanjukta and Das, Supriya and Maiti, Nakul C and Das, Padma and Chowdhury, Chinmay
Journal: European journal of medicinal chemistry (2015): 93-105

Novel metal-based pharmacologically dynamic agents of transition metal(II) complexes: designing, synthesis, structural elucidation, DNA binding and photo-induced DNA cleavage activity.
Authors: Raman, N and Jeyamurugan, R and Sakthivel, A and Mitu, L
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2010): 88-97

Synthesis, crystal structure, DNA binding and photo-induced DNA cleavage activity of (S-methyl-L-cysteine)copper(II) complexes of heterocyclic bases.
Authors: Patra, Ashis K and Nethaji, Munirathinam and Chakravarty, Akhil R
Journal: Journal of inorganic biochemistry (2007): 233-44

Metal-assisted light-induced DNA cleavage activity of 2-(methylthio)phenylsalicylaldimine Schiff base copper(II) complexes having planar heterocyclic bases.
Authors: Reddy, Pattubala A N and Santra, Bidyut K and Nethaji, Munirathinam and Chakravarty, Akhil R
Journal: Journal of inorganic biochemistry (2004): 377-86

Syntheses, crystal structures, and oxidative DNA cleavage of some Cu(II) complexes of 5-amino-3-pyridin-2-yl-1,2,4-triazole.
Authors: Ferrer, Sacramento and Ballesteros, Rafael and Sambartolomé, Ana and González, Marta and Alzuet, Gloria and Borrás, Joaquín and Liu, Malva
Journal: Journal of inorganic biochemistry (2004): 1436-46